The tumor suppressor protein p53 is mutated in more than half of all human cancers. Several drugs that potentially can restore mutant p53 to its normal cancer-killing function are in clinical investigation.
However, much remains to be learned about various mutations that lead to a “loss of function” in the protein and others that cause a putative malignant “gain of function,” acceleration of cancerous growth and spread (metastasis), for example.
- Read more about Recent cancer research therapies targeting mutant p53
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source https://www.pharmatutor.org/pharma-news/2021/recent-cancer-research-therapies-targeting-mutant-p53
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